Rapamycin of MTOR Inhibitor

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area:	Beijing
Expiry date :	Long Effective
last update:	2021-02-16 22:33
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Product details

Research Only! We don’t sell for human use.
Rapamycin, also known as sirolimus or AY-22989, is a specific mTOR inhibitor and has potent immunosuppressive and antiproliferative properties. It is used in coating coronary stents, treatment of lung diseases such as lymphangioleiomyomatosis and preventing organ transplant rejection, especially useful for kidney transplant rejection. By reducing the sensitivity to interleukin-2 (IL-2) through mTOR inhibiting, rapamycin inhibits activation of T cells and B cells.

Cat. No.	53123-88-9
Purity	99.94%
Target	mTOR, Autophagy, Human Endogenous Metabolite
IC50	0.1 nM (IC50, in HEK293 cells )
In Vitro	Lung Cancer Cell Lines: A549, SPC-A-1, 95D and NCI-H446 Incubation Time: 24hours Concentration at 100 nM: 30-40% reduction in cell proliferation Concentration at 12.5 nM: ~10% reduction in cell proliferation * Above data is for reference only. Accuracy is not confirmed.
In Vivo	Animal Model: 24 male nu/nu mice, aged 4-5 week old, weighted 15-20g Dosage: 2.0mg/kg Administration: Intraperitoneal injection every other day for 28 days Result: In monotherapy group, effect of inhibition is moderate. Significantly increased inhibitory effect of tumor growth is achieved when combined with Metformin. * Above data is for reference only. Accuracy is not confirmed.
Formula	C₅₁HH₇₉NO₁₃
SMILES	O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O
M. Weight	914.2
Storage	Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 month
Solvent & Solubility
Documentation	Contact us for relevant PDF documents.

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